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The partial NMDA agonist D-cycloserine stimulates LH secretion in healthy volunteers.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 1998 Jul; Vol. 138 (2), pp. 190-7. - Publication Year :
- 1998
-
Abstract
- D-Cycloserine, a partial agonist of the glycine recognition site of the N-methyl-D-aspartate (NMDA) receptor, may serve as a probe for human cerebral NMDA receptor function. Since NMDA receptors are involved in neuroendocrine secretion, changes in pituitary secretion in response to D-cycloserine administration could serve as a model for NMDA receptor activity. The effects of an oral dose of 500 mg D-cycloserine were assessed in a neuroendocrine challenge paradigm in 20 healthy male volunteers, using a double-blind, randomized placebo-controlled crossover design. Luteinizing hormone (LH) and cortisol secretion was studied, since preclinical studies indicate that these hormones increase in response to NMDA receptor stimulation. Furthermore, plasma homovanillic acid (HVA) secretion was studied, as NMDA receptors are suggested to be involved in the regulation of dopaminergic neurotransmission. D-cycloserine was readily absorbed and did not induce side-effects or changes in vital signs and mood scores. D-Cycloserine stimulated LH secretion and induced a significant rise of the area under the plasma concentration time curve of LH. D-Cycloserine did not stimulate cortisol or plasma HVA secretion. These neuroendocrine effects suggest that D-cycloserine may be used to assess human NMDA receptor function in cerebral disorders, such as schizophrenia.
- Subjects :
- Adult
Affect drug effects
Antipsychotic Agents adverse effects
Antipsychotic Agents blood
Antipsychotic Agents therapeutic use
Behavior drug effects
Blood Pressure drug effects
Body Temperature drug effects
Brief Psychiatric Rating Scale
Cross-Over Studies
Cycloserine adverse effects
Cycloserine blood
Cycloserine therapeutic use
Dopamine metabolism
Double-Blind Method
Heart Rate drug effects
Homovanillic Acid blood
Humans
Hydrocortisone blood
Hydrocortisone metabolism
Male
Neurosecretory Systems drug effects
Schizophrenia drug therapy
Antipsychotic Agents pharmacology
Cycloserine pharmacology
Luteinizing Hormone metabolism
N-Methylaspartate agonists
Receptors, N-Methyl-D-Aspartate metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 138
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9718289
- Full Text :
- https://doi.org/10.1007/s002130050662