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The IGF system during fetal-placental development of the mouse.

Authors :
van Kleffens M
Groffen C
Lindenbergh-Kortleve DJ
van Neck JW
González-Parra S
Dits N
Zwarthoff EC
Drop SL
Source :
Molecular and cellular endocrinology [Mol Cell Endocrinol] 1998 May 25; Vol. 140 (1-2), pp. 129-35.
Publication Year :
1998

Abstract

Insulin-like growth factors (IGF-I and -II) promote cellular mitosis and differentiation and have been implicated in fetal and placental growth. Together with the IGF receptors and IGF binding proteins (IGFBPs) they form a complex network, with tissue specific activity. This review will discuss the data generated to elucidate the functions of the IGF system during mouse development.

Subjects

Subjects :
Animals
Apoptosis
Female
Gene Deletion
Insulin-Like Growth Factor Binding Proteins analysis
Insulin-Like Growth Factor Binding Proteins genetics
Mice
Mice, Transgenic
Pregnancy
Receptor, IGF Type 2 genetics
Somatomedins analysis
Somatomedins genetics
Embryonic and Fetal Development physiology
Placenta physiology
Somatomedins physiology

Details

Language :
English
ISSN :
0303-7207
Volume :
140
Issue :
1-2
Database :
MEDLINE
Journal :
Molecular and cellular endocrinology
Publication Type :
Academic Journal
Accession number :
9722180
Full Text :
https://doi.org/10.1016/s0303-7207(98)00041-0
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