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[Detection of soluble interleukin-2 receptor in the serum of patients with non-Hodgkin's lymphoma].
- Source :
-
Medicina clinica [Med Clin (Barc)] 1998 Jul 11; Vol. 111 (5), pp. 161-7. - Publication Year :
- 1998
-
Abstract
- Background: Patients with non-Hodgkin's lymphoma (NHL) have increased serum levels of soluble interleukin-2 receptor (sCD25). In this study the authors investigate: a) the value of sCD25, compared to other serum markers, as tumor marker, and b) the relationship of the sCD25 with the response to therapy and prognosis.<br />Patients and Methods: Serum interleukin-2 receptor (sCD25) levels were measured at diagnosis in 63 patients with NHL (low-grade lymphoma 30 and high-grade lymphoma 33).<br />Results: High levels of sCD25 were found in these patients compared to a control group (median 1,757 U/ml vs 385 U/ml; p < 0.0001). Significant differences were also found between the high-grade group and the low-grade group, as a whole and within the same Ann Arbor stage. sCD25 showed a correlation coefficient higher than other serum parameters (albumin, LDH, beta 2-microglobulin, uric acid, C-reactive protein) with Ann Arbor stage and with the number of involved lymph nodes or extralymphatic organs. In the high-grade NHL, the median of sCD25 (3,000 U/ml) separates patients with differences in the overall survival (p = 0.0138) and in percentage of complete remisions (p = 0.0079). All the patients with sCD25 < or = 3,000 U/ml reached the remision. The association sCD25 > 3,000 U/ml and albumin < 3.5 g/dl selected to 5 out of 6 patients who failed induction chemotherapy, and only 2 out of 22 who reached the remision.<br />Conclusions: The sCD25 is the best serum factor for estimating tumor burden in NHL. sCD25 level isolates or associated with albumin provides prognostic information.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
C-Reactive Protein analysis
Data Interpretation, Statistical
Female
Humans
L-Lactate Dehydrogenase blood
Lymphoma, Non-Hodgkin mortality
Lymphoma, Non-Hodgkin pathology
Male
Middle Aged
Prognosis
Serum Albumin analysis
Solubility
Time Factors
Uric Acid blood
beta 2-Microglobulin analysis
Biomarkers, Tumor
Lymphoma, Non-Hodgkin blood
Receptors, Interleukin-2 blood
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0025-7753
- Volume :
- 111
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Medicina clinica
- Publication Type :
- Academic Journal
- Accession number :
- 9732831