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Circulatory effects of oral and subcutaneous administration in normal subjects of a new bronchodilator, ibuterol, a pro-drug to terbutaline.
- Source :
-
British journal of pharmacology [Br J Pharmacol] 1976 Sep; Vol. 58 (1), pp. 43-6. - Publication Year :
- 1976
-
Abstract
- 1 The di-isobutyryl ester of terbutaline, ibuterol, was given subcutaneously and orally to healthy volunteers and its effects on heart rate, arterial blood pressure, and ECG were compared with those of terbutaline itself. The effects of the two substances were qualitatively identical, but quantitatively different. 2 By mouth, ibuterol acted more rapidly, and was 2-3 times more active. After intramuscular injection, ibuterol caused less increase in local blood flow than terbutaline. 3 Ibuterol can be regarded as a pro-drug, which in itself has little activity, but which can be made active in the body.
- Subjects :
- Administration, Oral
Blood Pressure drug effects
Butyrates administration & dosage
Butyrates pharmacology
Electrocardiography
Heart Rate drug effects
Humans
Injections, Subcutaneous
Male
Muscles blood supply
Regional Blood Flow drug effects
Terbutaline administration & dosage
Terbutaline pharmacology
Time Factors
Hemodynamics drug effects
Terbutaline analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1188
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- British journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 974376
- Full Text :
- https://doi.org/10.1111/j.1476-5381.1976.tb07691.x