Discovery and development of GG745, a potent inhibitor of both isozymes of 5 alpha-reductase.

Authors :: Frye SV
Bramson HN
Hermann DJ
Lee FW
Sinhababu AK
Tian G
Source :: Pharmaceutical biotechnology [Pharm Biotechnol] 1998; Vol. 11, pp. 393-422.
Publication Year :: 1998

Subjects :: Animals
Azasteroids pharmacokinetics
Cholestenone 5 alpha-Reductase
Dihydrotestosterone metabolism
Dose-Response Relationship, Drug
Dutasteride
Finasteride pharmacology
Humans
Oxidoreductases physiology
Azasteroids pharmacology
Enzyme Inhibitors pharmacology
Isoenzymes antagonists & inhibitors
Oxidoreductases antagonists & inhibitors

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