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Glycosidopyrroles. Part 3. Effect of the benzocondensation on acyclic derivatives: 1-(2-hydroxyethoxy) methylindoles as potential antiviral agents.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1998 Jun 30; Vol. 53 (6), pp. 409-14. - Publication Year :
- 1998
-
Abstract
- The new of 1-(2-hydroxyethoxy)methylindole derivatives 3a-i were prepared in good yields. None of them showed any significant anti-HIV activity and therefore the benzocondensation between the 2 and 3 positions of the pyrrole ring definitely reduced the weak activity found in the analogues 1a-c.
- Subjects :
- Animals
Anti-HIV Agents pharmacology
Cell Line
Chlorocebus aethiops
Cytopathogenic Effect, Viral drug effects
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
HIV-1 drug effects
HIV-1 pathogenicity
Humans
Microbial Sensitivity Tests
Pyrroles pharmacology
Vero Cells
Virus Replication drug effects
Anti-HIV Agents chemistry
Indoles chemistry
Pyrroles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 53
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 9764473
- Full Text :
- https://doi.org/10.1016/s0014-827x(98)00042-1