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Tenascin-C is not a useful marker for disease activity in psoriasis.

Authors :
Latijnhouwers MA
Bergers M
Kuijpers AL
van der Vleuten CJ
Dijkman H
van de Kerkhof PC
Schalkwijk J
Source :
Acta dermato-venereologica [Acta Derm Venereol] 1998 Sep; Vol. 78 (5), pp. 331-4.
Publication Year :
1998

Abstract

Tenascin-C is an extracellular matrix glycoprotein that is markedly upregulated in the dermis of psoriatic skin. In this study, we have addressed the question whether the presence of tenascin-C in the lesion or in serum is a marker for disease activity. Immunohistochemical staining of tenascin-C before and after treatment with different topical and systemic medication showed that tenascin-C remained abundant after clinical remission of lesions, indicating that downregulation of tenascin-C to normal values is a slow process. By using a sensitive enzyme-linked immunosorbent assay to measure levels of serum tenascin-C in psoriatic patients and unaffected individuals, we found that tenascin-C levels in most patients were within the normal range. Moreover, tenascin-C values did not correlate with disease activity. We conclude that tenascin-C is not useful as a marker for disease activity in psoriasis.

Details

Language :
English
ISSN :
0001-5555
Volume :
78
Issue :
5
Database :
MEDLINE
Journal :
Acta dermato-venereologica
Publication Type :
Academic Journal
Accession number :
9779247
Full Text :
https://doi.org/10.1080/000155598442980