Back to Search
Start Over
Biological activities of endotoxins from Yersinia enterocolitica.
- Source :
-
Japanese journal of microbiology [Jpn J Microbiol] 1976 Aug; Vol. 20 (4), pp. 273-80. - Publication Year :
- 1976
-
Abstract
- The chemical properties and the general biological activities of lipopolysaccharide (LPS) and Boivin-type endotoxin obtained respectively by phenol-water and trichloroacetic acid extraction from Yersinia enterocolitica serotypes O3 and O9 were studied. The yield of LPS from the O9 strain was about 10% of the O3 strain possibly because of the lower solubility of O9-LPS in aqueous phase. However, the chemical composition of O9-LPS was similar to that of O3-LPS in the proportions of reducing sugar, glucosamine, heptose, KDO, and lipid A. In pyrogenicity and local Shwartzman reactivity in rabbits and lethality for mice, there was also no difference between O3 and O9-LPS. The anthrone-positive carbohydrate and lipid A contents of Boivin-type endotoxin from O3 were higher than those of the endotoxin from O9. The biological activities of Boivin-type endotoxin from O3 were also remarkably higher than those of the endotoxin from O9. It seems that endotoxin of Y. enterocolitica serotype O3 may play an important role in infection by this organism.
- Subjects :
- Adjuvants, Immunologic
Animals
Bacterial Proteins analysis
Carbohydrates analysis
Fever chemically induced
Glucosamine analysis
Lipid A analysis
Mice
Pyrogens
Rabbits
Shwartzman Phenomenon chemically induced
Endotoxins analysis
Endotoxins pharmacology
Lipopolysaccharides analysis
Lipopolysaccharides pharmacology
Polysaccharides, Bacterial analysis
Polysaccharides, Bacterial pharmacology
Yersinia analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5139
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese journal of microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 978837
- Full Text :
- https://doi.org/10.1111/j.1348-0421.1976.tb00988.x