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Lack of in vitro anti-gp160 antibody production is a correlate of nonprogression among HIV type 1-infected individuals.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 1998 Oct 10; Vol. 14 (15), pp. 1341-3. - Publication Year :
- 1998
-
Abstract
- The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4+ slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied and followed for 2 years. During the follow-up, in vitro anti-gp160 producers showed negative CD4+ slopes in the majority of cases (9 of 12), whereas 5 of 7 nonproducers showed positive CD4+ slopes. Plasma viremia values, which were not significantly different in the two groups at baseline, became significantly higher in anti-gp160 producers when compared with nonproducers during the follow-up (p = 0.012). Finally, a trend toward progression was observed in the group of producers but not in nonproducers. These findings suggest that the in vitro production of anti-gp160 antibodies by peripheral B cells is not a correlate of protection, and may represent an early predictor of progression in LTNPs.
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 14
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 9788675
- Full Text :
- https://doi.org/10.1089/aid.1998.14.1341