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Splenorenal shunt blood flow by transit-time ultrasound as an index of collateral circulation in portal hypertensive rats.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 1998 Nov; Vol. 28 (5), pp. 1269-74. - Publication Year :
- 1998
-
Abstract
- The aim of this study was to develop a technique that could serve as an index of portosystemic shunt (PSS) blood flow in portal hypertensive rats whose main shunt is the splenorenal shunt (SRS). The main hemodynamic measurements performed were: SRS blood flow by the transit-time ultrasound (TTU) method, percentage of PSS, and regional blood flows by the microsphere method. We determined the accuracy and reproducibility of SRS blood flow measurements under baseline and pharmacological (octreotide) conditions. SRS blood flow was compared with other hemodynamic characteristics. Two models of portal hypertension were used: secondary biliary and dimethylnitrosamine cirrhosis. The SRS blood flow was correlated with mesenteric (r = .76; P < .001) and splenic (r = .67; P < .01) PSS percentages. The intra- and interobserver agreements for SRS blood flow were excellent: ric = .99 and ric = .98, respectively. SRS blood flow was six times higher in portal hypertensive rats (0.6 +/- 0.7 mL . min-1 . 100 g-1) than in sham rats (0.1 +/- 0.1 mL . min-1 . 100 g-1 [P < .01]). Octreotide significantly decreased SRS blood flow but not mesenteric or splenic PSS percentages. SRS is the main PSS in rats. The measurement of SRS blood flow by TTU is accurate and reproducible. This method can be used to identify new mechanisms in hemodynamic studies that differ from those identified by the measurement of the percentage of PSS by the microsphere method, especially in pharmacological studies.
- Subjects :
- Animals
Blood Flow Velocity
Hemostatics pharmacology
Hypertension, Portal physiopathology
Male
Octreotide pharmacology
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Collateral Circulation
Hypertension, Portal diagnostic imaging
Kidney blood supply
Spleen blood supply
Splenorenal Shunt, Surgical
Ultrasonography methods
Subjects
Details
- Language :
- English
- ISSN :
- 0270-9139
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 9794911
- Full Text :
- https://doi.org/10.1002/hep.510280515