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Intravascular large B-cell lymphoma: the CD5 antigen is expressed by a subset of cases.
- Source :
-
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 1998 Oct; Vol. 11 (10), pp. 983-8. - Publication Year :
- 1998
-
Abstract
- The CD5 antigen is a T-cell associated marker that is also usually expressed by two B-cell neoplasms, chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma. We observed CD5 antigen expression in a subset of cases of intravascular large B-cell lymphoma (IVLBL), and we report here five cases. The patients, two men and three women, ranged in age from 59 to 81 years. Biopsy specimens were obtained from kidney, lung, bone marrow, abdominal wall, and neck, the latter involving a lymphangioma. All of the cases had histologic features typical of IVLBL, with large and atypical lymphoid cells located predominantly within blood vessels. Immunohistochemical studies performed using routinely fixed, paraffin-embedded tissue sections showed that the neoplastic cells were B cells, positive for the CD20 antigen and negative for the CD3 or CD43 antigens. All cases were also positive for the CD5 antigen. One case had an immunoglobulin heavy chain gene rearrangement shown by using a polymerase chain reaction method. The finding of CD5 antigen expression in a subset of IVLBL cases adds to other evidence in the literature suggesting that IVLBL is a heterogeneous entity. We considered the possibility that these cases were related to or represented unusual histologic forms of transformation from either chronic lymphocytic leukemia/small lymphocytic lymphoma or mantle cell lymphoma. All of the cases, however, were negative for the CD23 antigen and cyclin D1 (bcl-1) protein, which is evidence against this interpretation. The biologic significance of CD5 antigen expression in cases of IVLBL is uncertain. These neoplasms might arise from a separate lineage of CD5-positive B cells or from a specific, early stage of B-cell differentiation. Alternatively, some investigators have suggested that CD5 antigen expression by B cells is a marker of activation.
- Subjects :
- Aged
Aged, 80 and over
Antigens, CD20 metabolism
Biomarkers, Tumor metabolism
Bone Marrow Neoplasms metabolism
Bone Marrow Neoplasms pathology
DNA Primers chemistry
Female
Head and Neck Neoplasms metabolism
Head and Neck Neoplasms pathology
Hemangioendothelioma pathology
Humans
Immunoenzyme Techniques
Kidney Neoplasms metabolism
Kidney Neoplasms pathology
Lung Neoplasms metabolism
Lung Neoplasms pathology
Lymphangioma metabolism
Lymphangioma pathology
Lymphoma, B-Cell pathology
Lymphoma, Large B-Cell, Diffuse pathology
Male
Middle Aged
Polymerase Chain Reaction
Skin Neoplasms metabolism
Skin Neoplasms pathology
CD5 Antigens metabolism
Hemangioendothelioma metabolism
Lymphoma, B-Cell metabolism
Lymphoma, Large B-Cell, Diffuse metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0893-3952
- Volume :
- 11
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
- Publication Type :
- Academic Journal
- Accession number :
- 9796727