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Routine cultures of bone marrow and peripheral stem cell harvests: clinical impact, cost analysis, and review.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 1998 Oct; Vol. 27 (4), pp. 886-8. - Publication Year :
- 1998
-
Abstract
- The American Association of Blood Banks requires routine culture of hematopoietic progenitor cells prior to bone marrow transplantation. We sought to evaluate the cost of that requirement and the incidence and clinical significance of positive cultures. We performed a retrospective analysis of transplant recipients at our institution. Of the 605 patients for whom 1,934 consecutive cultures of harvests were done between December 1992 and February 1996, 11 had positive cultures. Six patients received a culture-positive harvest with no adverse effects. The total cost of cultures was $35,660 (U.S. $). In North America and worldwide in 1995, routine culture of harvests would have prevented 7.9 and 18.9 cases of bacteremia, respectively, at a cost of $95,000 per bacteremia prevented. We conclude that routine culture of hematopoietic progenitor cells yields low rates of positivity and that infusion of contaminated harvests rarely results in clinically adverse outcomes.
- Subjects :
- Adult
Bacterial Infections microbiology
Bacterial Infections prevention & control
Bone Marrow Cells cytology
Bone Marrow Transplantation economics
Health Care Costs
Hematopoietic Stem Cells cytology
Humans
Middle Aged
Mycoses microbiology
Mycoses prevention & control
Retrospective Studies
Bone Marrow Cells microbiology
Bone Marrow Transplantation adverse effects
Cell Culture Techniques economics
Cell Culture Techniques standards
Hematopoietic Stem Cells microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1058-4838
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 9798046
- Full Text :
- https://doi.org/10.1086/514956