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Autoantibodies against calpastatin in sera from patients with systemic sclerosis.
- Source :
-
The Journal of rheumatology [J Rheumatol] 1998 Nov; Vol. 25 (11), pp. 2135-9. - Publication Year :
- 1998
-
Abstract
- Objective: To determine the prevalence and clinical correlation of anti-calpastatin antibodies in patients with systemic sclerosis (SSc).<br />Methods: Serum samples from patients with limited cutaneous SSc (lSSc; n=36), diffuse cutaneous SSc (dSSc; n=27), and healthy control subjects (n=29) were examined by an ELISA using human recombinant calpastatin as antigens.<br />Results: IgG anti-calpastatin antibodies were positive in 15 (24%) of 63 patients with SSc, which was similar to the frequency of IgM anti-calpastatin antibody positivity (14/63, 22%). The presence of anticentromere antibodies was associated with the presence of IgG and/or IgM anti-calpastatin antibodies. The patients with SSc positive for IgG anti-calpastatin antibodies had significantly higher erythrocyte sedimentation rates (ESR) compared with those negative for IgG anti-calpastatin antibodies. Furthermore, the levels of IgG anti-calpastatin antibodies correlated positively with the levels of ESR. The patients with dSSc positive for IgM anti-calpastatin antibodies had significantly higher frequency of inflammatory joint and muscle involvement compared with those negative for IgM anti-calpastatin antibodies. Four (80%) of 5 patients with dSSc with both joint and muscle involvement produced IgM anti-calpastatin antibodies.<br />Conclusion: The presence of anti-calpastatin antibodies may be a clue to mechanisms of the inflammatory change occurring in SSc. Furthermore, the presence of anti-calpastatin antibodies could be a novel and useful serologic tool for recognizing patients with dSSc with inflammatory joint and muscle involvement.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Antinuclear immunology
Antibody Specificity physiology
Blood Sedimentation
Child
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G analysis
Male
Middle Aged
Reference Values
Scleroderma, Localized blood
Scleroderma, Localized immunology
Scleroderma, Localized physiopathology
Scleroderma, Systemic blood
Scleroderma, Systemic physiopathology
Autoantibodies analysis
Calcium-Binding Proteins immunology
Scleroderma, Systemic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 9818655