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Patterns of the immunohistochemical expression of melanoma-associated antigens and density of CD45R0+ activated T lymphocytes and L1-protein positive macrophages in primary cutaneous melanomas.
- Source :
-
International journal of molecular medicine [Int J Mol Med] 1998 Dec; Vol. 2 (6), pp. 721-4. - Publication Year :
- 1998
-
Abstract
- There is ample evidence for spontaneous antimelanoma immune reactivity mediated by melanocyte-differentiation-antigens (MDAs). Our aim was to determine whether MDA immunoreactivity is associated with increased tumour-infiltrating lymphocytes (TIL) and macrophages (TIM). A retrospective study was conducted in 30 medium and high grade primary cutaneous melanomas (PCM) as identified by CART-analysis. All of the cases had developed clinical evidence for metastasis within 3 years following surgical excision of the PCM. We used immunohistochemistry and computerized image analysis to quantify MDAs positive cells (Melan A/MART-1, gp100/Pmel 17/HMB45, tyrosinase), CD45R0-positive TIL and LI-protein-positive TIM. A stochastic relationship was present between the MDA immuno-reactivities and the densities in TIL and TIM. An inverse relationship was yielded between TIL and TIM. No specific pattern of PCM immunoreactivity for MDAs, TIL and TIM was found to predict metastases.
- Subjects :
- Antigens, Neoplasm
Cell Differentiation
Humans
Immunohistochemistry
Leukocyte Common Antigens metabolism
Leukocyte L1 Antigen Complex
MART-1 Antigen
Melanocytes immunology
Melanoma pathology
Monophenol Monooxygenase immunology
Monophenol Monooxygenase metabolism
Neoplasm Proteins immunology
Neoplasm Proteins metabolism
Proteins immunology
Proteins metabolism
gp100 Melanoma Antigen
Antigens, Tumor-Associated, Carbohydrate metabolism
Macrophages immunology
Melanoma immunology
Membrane Glycoproteins metabolism
Neural Cell Adhesion Molecules metabolism
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1107-3756
- Volume :
- 2
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 9850742
- Full Text :
- https://doi.org/10.3892/ijmm.2.6.721