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Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
Fission yeast Csk1 is a CAK-activating kinase (CAKAK).
- Source :
-
The EMBO journal [EMBO J] 1998 Dec 15; Vol. 17 (24), pp. 7230-8. - Publication Year :
- 1998
-
Abstract
- Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).
- Subjects :
- Amino Acid Sequence
Cell Cycle
Conserved Sequence
Cyclin H
Cyclins genetics
Cyclins metabolism
Drosophila Proteins
Enzyme Activation
Gene Dosage
Genes, Suppressor
Phosphorylation
Protein Serine-Threonine Kinases genetics
Cyclin-Dependent Kinase-Activating Kinase
Cyclin-Dependent Kinases metabolism
Protein Kinases metabolism
Protein Serine-Threonine Kinases metabolism
Schizosaccharomyces enzymology
Schizosaccharomyces pombe Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0261-4189
- Volume :
- 17
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 9857180
- Full Text :
- https://doi.org/10.1093/emboj/17.24.7230