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Fission yeast Csk1 is a CAK-activating kinase (CAKAK).

Fission yeast Csk1 is a CAK-activating kinase (CAKAK).

Authors :
Hermand D
Pihlak A
Westerling T
Damagnez V
Vandenhaute J
Cottarel G
Mäkelä TP
Source :
The EMBO journal [EMBO J] 1998 Dec 15; Vol. 17 (24), pp. 7230-8.
Publication Year :
1998

Abstract

Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-activating kinase (CAK). Two distinct CAK kinases have been described: in budding yeast Saccharomyces cerevisiae, the Cak1/Civ1 kinase is responsible for CAK activity. In several other species including human, Xenopus, Drosophila and fission yeast Schizosaccharomyces pombe, CAK has been identified as a complex homologous to CDK7-cyclin H (Mcs6-Mcs2 in fission yeast). Here we identify the fission yeast Csk1 kinase as an in vivo activating kinase of the Mcs6-Mcs2 CAK defining Csk1 as a CAK-activating kinase (CAKAK).

Details

Language :
English
ISSN :
0261-4189
Volume :
17
Issue :
24
Database :
MEDLINE
Journal :
The EMBO journal
Publication Type :
Academic Journal
Accession number :
9857180
Full Text :
https://doi.org/10.1093/emboj/17.24.7230