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[Investigations on the effect of "ecstasy" on cerebral glucose metabolism: an 18-FDG PET study].

Authors :
Schreckenberger M
Gouzoulis-Mayfrank E
Sabri O
Arning C
Tuttass T
Schulz G
Kaiser HJ
Wagenknecht G
Sass H
Büll U
Source :
Nuklearmedizin. Nuclear medicine [Nuklearmedizin] 1998; Vol. 37 (8), pp. 262-7.
Publication Year :
1998

Abstract

Purpose: The aim of the present study was to determine the acute effects of the "Ecstasy" analogue MDE (3, 4-methylendioxyethamphetamine) on the cerebral glucose metabolism (rMRGlu) of healthy volunteers.<br />Method: In a randomised double-blind trial, 16 healthy volunteers without a history of drug abuse were examined with 18-FDG PET 110-120 minutes after oral administration of 2 mg/kg MDE (n = 8) or placebo (n = 8). Beginning two minutes prior to radiotracer injection, a constant cognitive stimulation was maintained for 32 minutes using a word repetition paradigm in order to ensure constant and comparable mental conditions during cerebral 18-FDG uptake. Individual brain anatomy was represented using T1-weighted 3D flash MRI, followed by manual regionalisation into 108 regions-of-interest and PFT/MRI overlay. Absolute quantification of rMRGlu and comparison of glucose metabolism under MDE versus placebo were performed using Mann-Whitney U-test.<br />Results: Absolute global MRGlu was not significantly changed under MDE versus placebo (MDE: 41.8 +/- 11.1 mumol/min/100 g, placebo: 50.1 +/- 18.1 mumol/min/100 g, p = 0.298). The normalised regional metabolic data showed a significantly decreased rMRGlu in the bilateral frontal cortex: left frontal posterior (-7.1%, p < 0.05) and right prefrontal superior (-4.6%, p < 0.05). On the other hand, rMRGlu was significantly increased in the bilateral cerebellum (right: +10.1%, p < 0.05; left +7.6%, p < 0.05) and in the right putamen (+6.2%, p < 0.05).<br />Conclusions: The present study revealed acute neurometabolic changes under the "Ecstasy" analogon MDE indicating a fronto-striato-cerebellar dysbalance with parallels to other psychotropic substances and various endogenous psychoses respectively.

Details

Language :
German
ISSN :
0029-5566
Volume :
37
Issue :
8
Database :
MEDLINE
Journal :
Nuklearmedizin. Nuclear medicine
Publication Type :
Academic Journal
Accession number :
9868707