Back to Search Start Over

Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.

Authors :
Hanessian S
Huynh HK
Reddy GV
McNaughton-Smith G
Ernst B
Kolb HC
Magnani J
Sweeley C
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Oct 06; Vol. 8 (19), pp. 2803-8.
Publication Year :
1998

Abstract

Monocyclic and bicyclic lactam units representing beta-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.

Details

Language :
English
ISSN :
0960-894X
Volume :
8
Issue :
19
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
9873626
Full Text :
https://doi.org/10.1016/s0960-894x(98)00500-9