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Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Oct 06; Vol. 8 (19), pp. 2803-8. - Publication Year :
- 1998
-
Abstract
- Monocyclic and bicyclic lactam units representing beta-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.
- Subjects :
- Binding, Competitive
Carbohydrate Conformation
Carbohydrate Sequence
E-Selectin metabolism
Indolizines chemistry
Molecular Sequence Data
Oligosaccharides chemistry
Sialyl Lewis X Antigen
Structure-Activity Relationship
Substrate Specificity
beta-Lactams chemistry
Indolizines chemical synthesis
Indolizines metabolism
Oligosaccharides chemical synthesis
Oligosaccharides metabolism
P-Selectin metabolism
beta-Lactams chemical synthesis
beta-Lactams metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 8
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 9873626
- Full Text :
- https://doi.org/10.1016/s0960-894x(98)00500-9