Back to Search Start Over

Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non-Hodgkin lymphoma.

Authors :
Dave BJ
Pickering DL
Hess MM
Weisenburger DD
Armitage JO
Sanger WG
Source :
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 1999 Jan 15; Vol. 108 (2), pp. 120-6.
Publication Year :
1999

Abstract

Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymphoma (NHL). The cell division cycle 2-like 1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metaphases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58clk-1 DNA probe. Twenty-three cases exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case, CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.

Details

Language :
English
ISSN :
0165-4608
Volume :
108
Issue :
2
Database :
MEDLINE
Journal :
Cancer genetics and cytogenetics
Publication Type :
Academic Journal
Accession number :
9973938
Full Text :
https://doi.org/10.1016/s0165-4608(98)00138-1