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SYNTHESIS AND PHARMACOLOGY OF ILLUDALIC ACID AND ANALOGOUS CHEMICAL STRUCTURES

Authors :
Gaston, Robert, Jr
Publication Year :
2023

Abstract

Natural products are the foundation of modern medicine and an inspiration for chemical innovation. Developing new synthetic strategies to complex natural products drives synthetic innovation and promotes pharmacological exploration. As bioactive secondary metabolites of fungi, illudalic acid and associated analogs have unrealized medicinal potential due to synthetic limitations. Illudalic acid is notably the first selective covalent inhibitor of the LAR-PTPs, a class of enzymes linked to many human illnesses, including stimulant addiction. The chemistry herein focuses on optimizing synthetic routes to illudalic acid and associated analogs toward exploring their pharmaceutical potential. We report a second-generation synthesis of illudinine (55% overall yield), the alkaloid congener of illudalic acid, through the insertion of a small, linear nitrile. We also enhance our current 4-step illudalic acid synthesis via regioselective Vilsmeier- Haack formylation, taking advantage of bulky formamides. The high-yielding and regioselective Wolff rearrangement diazodimedone is another attractive way to assemble the illudalane core, but further exploration is needed to maximize it efficacy. Using an adapted benzannulation strategy, 25 illudalic acid analogs (illudalogs) containing a naphthalene core were prepared and screened against the LAR-PTP family. These are the most potent inhibitors reported to date, and coupled with their ease of synthesis (4-steps), make the illudalogs attractive chemotherapeutic scaffolds.

Details

Language :
English
Database :
OpenDissertations
Publication Type :
Dissertation/ Thesis
Accession number :
ddu.oai.researchrepository.wvu.edu.etd.12605