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Priming of CD8+ T cell responses to liver stage malaria parasite antigens.
- Source :
- Frontiers in Immunology; Nov2014, Vol. 5, p1-6, 6p
- Publication Year :
- 2014
-
Abstract
- While the role of malaria parasite-specific memory CD8<superscript>+</superscript> T cells in the control of exoerythrocytic stages of malaria infection is well documented and generally accepted, a debate is still ongoing regarding both the identity of the anatomic site where the activation of naive pathogen-specific T cells is taking place and contribution of different antigen presenting cells (APCs) into this process. Whereas some studies infer a role of professional APCs present in the lymph nodes draining the site of parasite injection by the mosquito, others argue in favor of the liver as a primary organ and hepatocytes as stimulators of naïve parasite-specific T cell responses. This review aims to critically analyze the current knowledge and outline new lines of research necessary to understand the induction of protective cellular immunity against the malaria parasite. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 5
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 100167638
- Full Text :
- https://doi.org/10.3389/fimmu.2014.00527