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A quantum dot-based microRNA nanosensor for point mutation assays.
- Source :
- Chemical Communications; 2014, Vol. 50 Issue 54, p7160-7162, 3p
- Publication Year :
- 2014
-
Abstract
- We have developed a quantum dot-based microRNA nanosensor for point mutation assays using primer generation-mediated rolling circle amplification. The proposed method exhibits high sensitivity with a detection limit of as low as 50.9 aM and a large dynamic range of 7 orders of magnitude from 0.1 fM to 1 nM. Importantly, this method can be further applied to analyze the point mutation of mir-196a2 in the lung tissues of non small-cell lung cancer patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 50
- Issue :
- 54
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 100182122
- Full Text :
- https://doi.org/10.1039/c4cc02034k