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Correlation between ovarian chocolate cyst and serum carbohydrate antigen 125 level and the effect of ultrasound-guided interventional sclerotherapy on serum carbohydrate antigen 125 level.
- Source :
- Journal of Obstetrics & Gynaecology Research; Jan2015, Vol. 41 Issue 1, p92-98, 7p, 1 Color Photograph, 3 Charts
- Publication Year :
- 2015
-
Abstract
- Aim This study was to investigate the correlation between ovarian chocolate cysts and serum carbohydrate antigen ( CA)-125 levels and to demonstrate the effect of ultrasound-guided interventional sclerotherapy ( UGIS) on serum CA-125 levels. Methods Based on the serum CA-125 level, as determined by chemiluminescence detection prior to UGIS, 105 patients with ovarian chocolate cysts were divided into the normal group ( CA-125 ≤ 35 U/mL, 45 patients) and the abnormal group (35 U/mL < CA-125 ≤ 200 U/mL, 60 patients). There were six clinical indicators including age, disease duration, dysmenorrhea history, child-bearing history, abortion history and surgical history. The ultrasonography characteristics were cyst diameter, cyst wall thickness and the side on which the cyst occurred. The correlations between serum CA-125 levels pretreatment and the clinical indicators and ultrasonography characteristics was analyzed. The serum CA-125 levels pretreatment, 3 months post-treatment and 6 months post-treatment were compared. Results The pretreatment serum CA-125 levels of the 105 patients positively correlated with disease duration ( r = 0.3932, P = 0.0040), dysmenorrhea history ( r = 0.2351, P = 0.0111), cyst diameter ( r = 0.3415, P < 0.0001) and cyst wall thickness ( r = 0.4263, P < 0.0001). Compared with the pretreatment level, the mean serum CA-125 level in the abnormal group at 3 months post-treatment was significantly lower ( P < 0.01), and at 6 months post-treatment, the mean serum CA-125 level had decreased to a normal level ( P < 0.01). Conclusion UGIS significantly decreased abnormal serum CA-125 levels in patients with ovarian chocolate cysts. [ABSTRACT FROM AUTHOR]
- Subjects :
- ACADEMIC medical centers
ANALYSIS of variance
CHEMILUMINESCENCE assay
CHI-squared test
ENDOSCOPIC ultrasonography
SCLEROTHERAPY
COMPUTERS in medicine
RESEARCH funding
STATISTICS
THERAPEUTICS
TUMOR antigens
DATA analysis
OVARIAN cysts
PRE-tests & post-tests
REPEATED measures design
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 13418076
- Volume :
- 41
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Obstetrics & Gynaecology Research
- Publication Type :
- Academic Journal
- Accession number :
- 100320722
- Full Text :
- https://doi.org/10.1111/jog.12491