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BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid.
- Source :
- Retrovirology; 2014, Vol. 11 Issue 1, preceding p1-12, 13p
- Publication Year :
- 2014
-
Abstract
- Background The recently discovered small-molecule BI-2 potently blocks HIV-1 infection. BI-2 binds to the N-terminal domain of HIV-1 capsid. BI-2 utilizes the same capsid pocket used by the small molecule PF74. Although both drugs bind to the same pocket, it has been proposed that BI-2 used a different mechanism to block HIV-1 infection when compared to PF74. Findings This work demonstrates that BI-2 destabilizes the HIV-1 core during infection, and prevents the binding of the cellular factor CPSF6 to the HIV-1 core. Conclusions Overall this short-form paper suggests that BI-2 is using a similar mechanism to the one used by PF74 to block HIV-1 infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- SMALL molecules
HIV infections
CAPSIDS
CARRIER proteins
DNA metabolism
RETROVIRUSES
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 100335310
- Full Text :
- https://doi.org/10.1186/s12977-014-0120-x