Back to Search
Start Over
Mn2+-doped NaYF4:Yb/Er upconversion nanoparticles with amplified electrogenerated chemiluminescence for tumor biomarker detection.
- Source :
- Journal of Materials Chemistry B; 2014, Vol. 2 Issue 38, p6626-6633, 8p, 2 Charts
- Publication Year :
- 2014
-
Abstract
- Chemiluminescence was used as an excitation light source to construct a universal photoelectrochemical platform based on Mn<superscript>2+</superscript>-doped NaYF<subscript>4</subscript>:Yb/Er upconversion nanoparticles, which greatly improves the electrochemiluminescence intensity and offers more stable cathodic signals compared to pure NaYF<subscript>4</subscript>:Yb/Er NPs. Here, we report for the first time the ECL behaviors of Mn<superscript>2+</superscript>-doped NaYF<subscript>4</subscript>:Yb/Er NPs, which were synthesized via a facile strategy. Mn<superscript>2+</superscript> doping resulted in a 4-fold ECL intensity enhancement of NaYF<subscript>4</subscript>:Yb/Er. The characteristics of Mn<superscript>2+</superscript>-doped NaYF<subscript>4</subscript>:Yb/Er nanocomposites were obtained using transmission electron microscopy (TEM), energy dispersive X-ray spectrometer (EDS), and fluorescence spectra. After all the results had indicated that NaYF<subscript>4</subscript>:Yb/Er upconversion nanoparticles were successfully doped with Mn[sup 2+], the electrochemiluminescence platform was built. The as-prepared NaYF<subscript>4</subscript>:Yb/Er NPs were rendered water-soluble and then employed as ECL emitters for carcinoembryonic antigen (CEA) determination. The results indicated that the modified electrode can be used to determine CEA without interference from non-specific proteins, with a low detection limit of 5.2 pg mL<superscript>-1</superscript>. The biosensor can also be used for quantification of the CEA concentration in real samples. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 2
- Issue :
- 38
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 100494236
- Full Text :
- https://doi.org/10.1039/c4tb00717d