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Role of first trimester total testosterone in prediction of subsequent gestational diabetes mellitus.

Authors :
Gözükara, Yavuz M.
Aytan, Hakan
Ertunc, Devrim
Tok, Ekrem C.
Demirtürk, Fazli
Şahin, Şemsettin
Aytan, Pelin
Source :
Journal of Obstetrics & Gynaecology Research; Feb2015, Vol. 41 Issue 2, p193-198, 6p, 2 Charts, 2 Graphs
Publication Year :
2015

Abstract

Aim To assess the role of first trimester maternal testosterone and dehydroepiandrosterone sulfate ( DHEA-S) levels in prediction of development of gestational diabetes mellitus ( GDM). Methods Four hundred and fifty pregnant women were included in this prospective cohort study. All pregnant women with a singleton pregnancy who were not diabetic, had no family history of diabetes, had no history of previous GDM, were of white race and non-smokers were enrolled. Total testosterone and DHEA-S were measured at 11-14 weeks of gestation. The patients were called for routine pregnancy visits and followed accordingly. Forty-two patients did not come to their visits and were excluded. During gestational weeks 24-28, the remaining 408 patients were screened for GDM. The total testosterone and DHEA-S levels were compared between patients with and without GDM. Regression and receiver-operator curve analysis were performed. Results GDM developed in 22 women (5.7%). Compared with women without GDM, first trimester total testosterone levels were higher among women in whom GDM subsequently developed. The DHEA-S level did not differ. Age, total testosterone and body mass index were found to be independent predictors of GDM development. A total testosterone value of 0.45 ng/mL was found to predict development of GDM with a sensitivity of 63.6% and a specificity of 62.7%. Conclusion First trimester total testosterone has a low testing power for GDM screening with low sensitivity and specificity values and cannot be used as a marker alone. It may have a role in combination with other markers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13418076
Volume :
41
Issue :
2
Database :
Complementary Index
Journal :
Journal of Obstetrics & Gynaecology Research
Publication Type :
Academic Journal
Accession number :
100633046
Full Text :
https://doi.org/10.1111/jog.12525