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Differential regulation patterns of the anti-CD20 antibodies obinutuzumab and rituximab in mantle cell lymphoma.

Authors :
Heinrich, Daniel A.
Weinkauf, Marc
Hutter, Grit
Zimmermann, Yvonne
Jurinovic, Vindi
Hiddemann, Wolfgang
Dreyling, Martin
Source :
British Journal of Haematology; Feb2015, Vol. 168 Issue 4, p606-610, 4p
Publication Year :
2015

Abstract

The article discusses the anti-CD20 antibodies rituximab and obinutuzumab and their differential regulation pattern in mantle cell lymphoma. Topics include information on Mantle cell lymphoma (MCL), the higher reduction in cell viability of every MCL cell line of Obinutuzumab as compared to rituximab, and the need for more combination experiments to show potential additive effects in MCL therapy.

Details

Language :
English
ISSN :
00071048
Volume :
168
Issue :
4
Database :
Complementary Index
Journal :
British Journal of Haematology
Publication Type :
Academic Journal
Accession number :
100711629
Full Text :
https://doi.org/10.1111/bjh.13132