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Critical peripheral ischemia precipitated by severe episode of Raynaud’s phenomenon in a patient with aPL-positive systemic lupus erythematosus, upon high titer anti-RNP seroconversion.
Critical peripheral ischemia precipitated by severe episode of Raynaud’s phenomenon in a patient with aPL-positive systemic lupus erythematosus, upon high titer anti-RNP seroconversion.
- Source :
- Lupus; Mar2015, Vol. 24 Issue 3, p327-330, 4p, 2 Color Photographs, 1 Chart
- Publication Year :
- 2015
-
Abstract
- A 35-year-old female with long standing aPL-positive lupus without history of thromboembolic events, who has developed critical peripheral ischemia (CPI) is described. An episode of severe Raynaud's phenomenon rapidly progressed to an extensive digit-threatening ischemia, involving bilateral hands and feet. She was successfully treated with corticosteroids, anticoagulation, iloprost, sildenafil, and nifedipine. Her serological studies were remarkable for the emergence of high titer anti-RNP seroconversion and an increase in aPL titer, suggesting that these autoantibodies played a role in the pathogenesis of CPI. It is important to note that such observation should herald this potentially devastating complication of systemic lupus erythematosus. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 09612033
- Volume :
- 24
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 100948387
- Full Text :
- https://doi.org/10.1177/0961203314560427