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Critical peripheral ischemia precipitated by severe episode of Raynaud’s phenomenon in a patient with aPL-positive systemic lupus erythematosus, upon high titer anti-RNP seroconversion.

Critical peripheral ischemia precipitated by severe episode of Raynaud’s phenomenon in a patient with aPL-positive systemic lupus erythematosus, upon high titer anti-RNP seroconversion.

Authors :
Levy, O
Maslakov, I
Vosco, S
Markov, A
Amit-Vazina, M
Tishler, M
Source :
Lupus; Mar2015, Vol. 24 Issue 3, p327-330, 4p, 2 Color Photographs, 1 Chart
Publication Year :
2015

Abstract

A 35-year-old female with long standing aPL-positive lupus without history of thromboembolic events, who has developed critical peripheral ischemia (CPI) is described. An episode of severe Raynaud's phenomenon rapidly progressed to an extensive digit-threatening ischemia, involving bilateral hands and feet. She was successfully treated with corticosteroids, anticoagulation, iloprost, sildenafil, and nifedipine. Her serological studies were remarkable for the emergence of high titer anti-RNP seroconversion and an increase in aPL titer, suggesting that these autoantibodies played a role in the pathogenesis of CPI. It is important to note that such observation should herald this potentially devastating complication of systemic lupus erythematosus. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
09612033
Volume :
24
Issue :
3
Database :
Complementary Index
Journal :
Lupus
Publication Type :
Academic Journal
Accession number :
100948387
Full Text :
https://doi.org/10.1177/0961203314560427