Aspirin Causes of Upper Gastrointestinal Bleeding Risk Factor Analysis.

Objective: To compare the OR values of the risk factors that are associated with upper gastrointestinal hemorrhage caused by aspirin. Methods: 100 cases of patients who had taken aspirin orally as the only NSAID (non-steroidal anti-inflammatory drug) and hospitalized at Digestive System Department and Cardiology Department of the Fourth Affiliated Hospital of Harbin Medical University were selected, 49 cases of whom had upper gastrointestinal bleeding caused by medicine were selected as research group, and the other 51 cases were used as control group. History of present illness, past medical illness, smoking history, coagulation routine, HP testing and gastroscopy were collected to screen out risk factors that led to upper gastrointestinal hermorrhage caused by aspirin through single factor statistical analysis, and to work out the independent risk factors through multiple Logistic regression analysis. Results: Patients at age over 60 or with history of Hp infection, ulceration, diabetes, and smoking took an apparently higher rate in the research group that in the control group, with statistical significance. Through multiple Logistic regression, it was indicated that there was statistical difference among age over 60 or with history of Hp infection, ulceration, diabetes, and the OR value of upper gastrointestinal hermorrhage caused by aspirin. Conclusions: Age over 60, history of Hp infection, ulceration, diabetes are risk factors which lead to upper gastrointestinal hermorrhage caused by aspirin. [ABSTRACT FROM AUTHOR]