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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
- Source :
- Nature Immunology; Jul2003, Vol. 4 Issue 7, p670, 10p
- Publication Year :
- 2003
-
Abstract
- During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T[SUBH]1) but not T[SUBH]2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
LYMPHOCYTES
GLYCOPROTEINS
TYROSINE
PHOSPHORYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 4
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 10121860
- Full Text :
- https://doi.org/10.1038/ni944