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Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5.
- Source :
- Frontiers in Immunology; Dec2014, Vol. 5, p1-4, 4p
- Publication Year :
- 2014
-
Abstract
- This is a perspective based on the paper "Cloning of complementary DNA encoding T cell-replacing factor and identity with B cell growth factor II," by Kinashi et al. (1). We have been interested in understanding the molecular basis ofT-B cell cooperation for antibody formation. Although many investigators had described a number of different soluble factors that appeared to have biological relevance to T-B cell interactions, molecular basis of such active substances remained unknown for a long period of time. In this perspective, I will briefly summarize the history of the initial discovery of T cell-replacing factor/B cell growth factor II that appeared to be involved in B cell growth and differentiation, and outline the discovery and characterization of interleukin-5. Studies of interleukin-5 have provided strong evidence that a single cytokine exerts a variety of activities on diverse target cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTISENSE DNA
T cells
B cells
IMMUNOGLOBULINS
CELL differentiation
INTERLEUKIN-5
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 5
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 101665262
- Full Text :
- https://doi.org/10.3389/fimmu.2014.00639