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Eupartoium makinoi suppresses lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression.
- Source :
- Food & Agricultural Immunology; Jul2015, Vol. 26 Issue 4, p496-503, 8p
- Publication Year :
- 2015
-
Abstract
- Inflammation is involved in numerous diseases including cancer. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play important roles in the development of certain inflammatory diseases.Eupatorium makinoi, which belongs to a family ofAsteraceaeplants, is used medicinally in East Asia. We investigated the effects of an ethanol extract ofE. makinoi(EEM) on nuclear factor-kappa B (NF-κB) activation and the expression of iNOS and COX-2 with lipopolysaccharide (TLR4 agonist) in murine macrophages. EEM suppressed NF-κB activation and iNOS and COX-2 expression induced by LPS. These results suggest that EEM may regulate TLR4 signalling pathways and this may be a useful strategy for anti-inflammatory therapies. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 09540105
- Volume :
- 26
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Food & Agricultural Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 101792037
- Full Text :
- https://doi.org/10.1080/09540105.2014.968768