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Lectin Complement Protein Collectin 11 (CL-K1) and Susceptibility to Urinary Schistosomiasis.
- Source :
- PLoS Neglected Tropical Diseases; Mar2015, Vol. 9 Issue 3, p1-16, 16p
- Publication Year :
- 2015
-
Abstract
- Background: Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose. Methodology/Principal Findings: We utilized a Nigerian study group consisting of 167 Schistosoma haematobium infected individuals and 186 matched healthy subjects, and investigated the contribution of CL-K1 deficiency and of COLEC11 polymorphisms to infection phenotype. Higher CL-K1 serum levels were associated with decreased risk of schistosome infection (P<superscript>corr</superscript> = 0.0004). CL-K1 serum levels were differentially distributed between the COLEC11 genotypes and haplotypes observed. The non-synonymous variant p.R216H was associated with the occurrence of schistosomiasis (OR = 0.44, 95%CI = 0.22–0.72, P<superscript>corr</superscript> = 0.0004). The reconstructed COLEC11*TCCA haplotypes were associated with higher CL-K1 serum levels (P = 0.002) and with decreased schistosomiasis (OR = 0.38, 95%CI = 0.23–0.63, P<superscript>corr</superscript> = 0.0001). Conclusions: In agreement with findings from our earlier published study, our findings support the observation that CL-K1 and their functional variants may be host factors associated with protection in schistosomiasis and may be a useful marker for further investigations. [ABSTRACT FROM AUTHOR]
- Subjects :
- SCHISTOSOMIASIS
LECTIN genetics
COLLECTINS
PATTERN perception
SCHISTOSOMA
Subjects
Details
- Language :
- English
- ISSN :
- 19352727
- Volume :
- 9
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- PLoS Neglected Tropical Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 101840236
- Full Text :
- https://doi.org/10.1371/journal.pntd.0003647