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Proteolytic activity and cytokine up-regulation by non- albicans Candida albicans.
- Source :
- Archives of Microbiology; May2015, Vol. 197 Issue 4, p533-537, 5p
- Publication Year :
- 2015
-
Abstract
- Mouth is an important source of infections and oral infections such as Candida infections increase the risk of mortality. Our purpose was to investigate differences in proteolytic activity of non- albicans Candida albicans (non- albicans Candida) between clinical isolates and laboratory samples. The second aim was to assess the concentration of pro- and anti-inflammatory cytokine levels IL-1β, IL-10, and TNF-α in saliva of patients with the non- albicans Candida and Candida-negative saliva samples. Clinical yeast samples from our laboratory were used for analyses. Candida strains were grown in YPG at 37 °C for 24 h in water bath with shaking. The activity of Candida proteinases of cell and cell-free fractions were analyzed by MDPF-gelatin zymography. The levels of IL-1β, IL-10, and TNF-α were measured from saliva with ELISA. The study showed differences in the proteolytic activity among the non- albicans Candida strain s. C. tropicalis had higher proteolytic activity when compared to the other strains. Significant difference was found in salivary IL-1β levels between the non- albicans Candida and control strains ( P < 0.002). The present findings showed differences in proteolytic activity among the non- albicans Candida strains. The increased IL-1β concentration may be one of the host response components associated with non- albicans Candida infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03028933
- Volume :
- 197
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Archives of Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 102103540
- Full Text :
- https://doi.org/10.1007/s00203-015-1083-6