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Mannosylated solid lipid nanoparticles for lung-targeted delivery of Paclitaxel.
- Source :
- Drug Development & Industrial Pharmacy; Apr2015, Vol. 41 Issue 4, p640-649, 10p
- Publication Year :
- 2015
-
Abstract
- Objective: The present study discusses paclitaxel (PTX)-loaded mannosylated-DSPE (Distearoyl-phosphatidyl-ethanolamine) solid lipid nanoparticles (M-SLNs) using mannose as a lectin receptor ligand conjugate for lung cancer targeting and to increase the anticancer activity of PTX against A549 lung's epithelial cancer cells. Materials and methods: The PTX-SLNs were prepared by solvent injection method and mannose was conjugated to the free amine group of stearylamine. The M-SLNs obtained were characterized for their particle size, polydispersity index, zeta potential and morphology by transmission electron microscope. Results: The M-SLNs were spherical in shape with 254 ± 2.3 nm average size, positive zeta potential (3.27 mV), 79.4 ± 1.6 drug entrapment efficiency and showed the lower extent of drug release 40% over 48 h in vitro. Cytotoxicity study on A549 cell lines and biodistrubtion study of drug revealed that M-SLNs deliver a higher concentration of PTX as compared to PTX-SLNs in an alveolar cell site. Discussion and conclusion: These results suggested that mannosylated M-SLNs are safe and potential vector for lung cancer targeting. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03639045
- Volume :
- 41
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Drug Development & Industrial Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 102289314
- Full Text :
- https://doi.org/10.3109/03639045.2014.891130