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Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO2 Nanoparticles.
- Source :
- PLoS ONE; Apr2015, Vol. 10 Issue 4, p1-18, 18p
- Publication Year :
- 2015
-
Abstract
- This study aims to investigate the potential nanotoxic effects of TiO<subscript>2</subscript> nanoparticles (TNPs) to dams and pups during lactation period. TiO<subscript>2</subscript> nanoparticles are accumulated in mammary glands of lactating mice after i.v. administration. This accumulation of TiO<subscript>2</subscript> NP likely causes a ROS-induced disruption of tight junction of the blood-milk barrier as indicated by the loss of tight junction proteins and the shedding of alveolar epithelial cells. Compared to larger TNPs (50 nm), smaller ones (8 nm) exhibit a higher accumulation in mammary glands and are more potent in causing perturbations to blood-milk barrier. An alarming finding is that the smaller TNPs (8 nm) are transferred from dams to pups through breastfeeding, likely through the disrupted blood-milk barrier. However, during the lactation period, the nutrient quality of milk from dams and the early developmental landmarks of the pups are not affected by above perturbations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 102402139
- Full Text :
- https://doi.org/10.1371/journal.pone.0122591