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Reversal of enantioselective Friedel–Crafts C3-alkylation of pyrrole by slightly tuning the amide units of N,N′-dioxide ligands.
- Source :
- Chemical Communications; 5/18/2015, Vol. 51 Issue 40, p8432-8435, 4p
- Publication Year :
- 2015
-
Abstract
- Chiral Ni(ii)-complexes of N,N′-dioxides show high catalytic activity and enantioselectivity in catalysing the asymmetric Friedel–Crafts C3-alkylation of 2,5-dimethyl pyrrole to β,γ-unsaturated α-ketoesters. A dramatic reversal of enantioselectivity is realized with ligands derived from the same type of chiral source of l-ramipril, by slightly tuning the amide units. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYRROLES
FRIEDEL-Crafts reaction
ALKYLATION
NICKEL oxides
LIGANDS (Chemistry)
AMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 51
- Issue :
- 40
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 102465983
- Full Text :
- https://doi.org/10.1039/c4cc10055g