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Keyhole limpet haemocyanin - a model antigen for human immunotoxicological studies.
- Source :
- British Journal of Clinical Pharmacology; Nov2014, Vol. 78 Issue 5, p1135-1142, 8p, 2 Charts
- Publication Year :
- 2014
-
Abstract
- Immunization with a T-cell dependent antigen has been promoted as a reliable and sensitive tool for assessing the influence of putative immunotoxic exposures or agents on immune function. Keyhole limpet haemocyanin (KLH) is a very large, copper-containing protein molecule derived from the haemolymph of the inedible mollusc, Megathura crenulata. KLH is a highly immunogenic T-cell dependent antigen that is used increasingly in immunotoxicological studies, particularly in those involving animals. This report systematically reviews the human clinical studies that have used trans-cutaneous KLH immunization for assessment of the influence of various physiological and disease states and exposures on immune function over the last 20 years (1994-2013). These studies varied in their immunization protocols, formulation of KLH, dose, site and route of administration and immunoassay platforms developed to assess KLH-specific responses. KLH immunization has been well tolerated with only mild to moderate adverse effects reported. Though very promising as a model antigen candidate in immunotoxicology research, more work on standardizing immunization and immunoassay protocols is required. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNIZATION
T cells
IMMUNOTOXICOLOGY
FISSURELLIDAE
HEMOCYANIN
IMMUNOASSAY
Subjects
Details
- Language :
- English
- ISSN :
- 03065251
- Volume :
- 78
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 102562769
- Full Text :
- https://doi.org/10.1111/bcp.12422