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Cystatin C is a disease-associated protein subject to multiple regulation.
- Source :
- Immunology & Cell Biology; May2015, Vol. 93 Issue 5, p442-451, 10p
- Publication Year :
- 2015
-
Abstract
- A protease inhibitor, cystatin C (Cst C), is a secreted cysteine protease inhibitor abundantly expressed in body fluids. Clinically, it is mostly used to measure glomerular filtration rate as a marker for kidney function due to its relatively small molecular weight and easy detection. However, recent findings suggest that Cst C is regulated at both transcriptional and post-translational levels, and Cst C production from haematopoietic cell lineages contributes significantly to the systematic pools of Cst C. Furthermore, Cst C is directly linked to many pathologic processes through various mechanisms. Thus fluctuation of Cst C levels might have serious clinical implications rather than a mere reflection of kidney functions. Here, we summarize the pathophysiological roles of Cst C dependent and independent on its inhibition of proteases, outline its change of expression by various stimuli, and elucidate the regulatory mechanisms to control this disease-related protease inhibitor. Finally, we discuss the clinical implications of these findings for translational gains. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 93
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 102875150
- Full Text :
- https://doi.org/10.1038/icb.2014.121