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Effect of Culture Conditions on Metabolite Production of Xylaria sp.
- Source :
- Molecules; May2015, Vol. 20 Issue 5, p7940-7950, 11p, 2 Diagrams, 3 Charts
- Publication Year :
- 2015
-
Abstract
- Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 1-5 to six new α-pyrone derivatives, xylapyrones A-F (compounds 6-11), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 1-3 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC<subscript>50</subscript> values ranging from 25 to 63 μM and compounds 4-11 were found to be inactive, with ICY<subscript>50</subscript> values >100 μM. [ABSTRACT FROM AUTHOR]
- Subjects :
- XYLARIA
NATURAL products
CYTOCHALASINS
PLANT metabolites
CELL-mediated cytotoxicity
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 20
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 102889089
- Full Text :
- https://doi.org/10.3390/molecules20057940