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Gypenosides attenuate the development of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
- Source :
- BMC Neuroscience; 2015, Vol. 16 Issue 1, p1-10, 10p, 1 Diagram, 5 Graphs
- Publication Year :
- 2015
-
Abstract
- Background: Gypenosides (GPS) and ethanol extract of Gynostemma pentaphyllum (GP-EX) show anxiolytic effects on affective disorders in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD). Long-term administration of L-3,4-dihydroxyphenylalanine (L-DOPA) leads to the development of severe motor side effects such as L-DOPA-induced-dyskinesia (LID) in PD. The present study investigated the effects of GPS and GP-EX on LID in a 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD. Results: Daily administration of L-DOPA (25 mg/kg) in the 6-OHDA-lesioned rat model of PD for 22 days induced expression of LID, which was determined by the body and locomotive AIMs scores and contralateral rotational behaviors. However, co-treatments of GPS (25 and 50 mg/kg) or GP-EX (50 mg/kg) with L-DOPA significantly attenuated the development of LID without compromising the anti-parkinsonian effects of L-DOPA. In addition, the increases in ΔFosB expression and ERK1/2 phosphorylation in 6-OHDA-lesioned rats induced by L-DOPA administration were significantly reduced by co-treatment with GPS (25 and 50 mg/kg) or GP-EX (50 mg/kg). Conclusion: These results suggest that GPS (25 and 50 mg/kg) and GP-EX (50 mg/kg) effectively attenuate the development of LID by modulating the biomarker activities of ΔFosB expression and ERK1/2 phosphorylation in the 6-OHDA-lesioned rat model of PD. GPS and GP-EX will be useful adjuvant therapeutics for LID in PD. [ABSTRACT FROM AUTHOR]
- Subjects :
- DOPA
DYSKINESIAS
PARKINSON'S disease
BRAIN diseases
LABORATORY rats
Subjects
Details
- Language :
- English
- ISSN :
- 14712202
- Volume :
- 16
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 102985692
- Full Text :
- https://doi.org/10.1186/s12868-015-0163-5