Enantio- and Diastereoselective Synthesis of Tetrahydrofurochromenes by Sequential Asymmetric Homoaldol Reaction and a Mukaiyama-Type Tetrahydrofuran Cyclization.

Herein, we report on a flexible strategy for the stereoselective construction of highly substituted tetrahydrofurochromene derivatives by Mukaiyama-type cyclizations of enantioenriched enol carbamates with O-protected salicylaldehydes. The chromenes are generated as pure diastereomers and under complete chirality transfer. [ABSTRACT FROM AUTHOR]