Colonic polyposis syndromes-An experience from a tertiary centre in South India.

Background: Several polyposis syndromes of the gastrointestinal tract have been recognized which carry increased risk for cancer and have a genetic predisposition. There is a paucity of literature regarding the occurrence and the burden of colonic polyposis syndromes in the Indian subcontinent. This study attempts to highlight this hitherto unaddressed burden and the associated increased risk for inherited colonic cancer in this geographical location. Methods: A retrospective study of various colonic polyposis syndromes encountered at a tertiary centre in South India over a period of 8 years (2005 to 2012) was performed. The diagnosis in each case was made histologically with clinicopathological correlation. Results: Fifty cases were identified as belonging to a colonic polyposis syndrome, during the study period. There were 27 males and 23 females with a median age of 36.5 years (range 19 months to 78 years). The commonest syndrome was familial adenomatous polyposis ( n = 27; 54 %) followed by Peutz-Jeghers syndrome ( n = 11), attenuated familial adenomatous polyposis ( n = 7), juvenile polyposis syndrome ( n = 3), hyperplasic polyposis syndrome ( n = 1) and Cronkhite-Canada syndrome ( n = 1). Colonic malignancy was documented at first presentation in 22 patients (44 %). Conclusions: Our study highlights the various colonic polyposis syndromes encountered in a tertiary care institution in Southern India. [ABSTRACT FROM AUTHOR]