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Association between statin use and Bell's palsy: a population-based study.
- Source :
- Drug Safety; Sep2014, Vol. 37 Issue 9, p735-742, 8p
- Publication Year :
- 2014
-
Abstract
- <bold>Background: </bold>Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity.<bold>Objective: </bold>This study aimed to evaluate the association between statin use and Bell's palsy using a population-based health insurance database.<bold>Methods: </bold>This case-control study identified 1,977 subjects with Bell's palsy as cases and 5,931 sex- and age-matched subjects without Bell's palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell's palsy were further analyzed.<bold>Results: </bold>By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4%, p < 0.001). Conditional logistic regression analysis revealed that after adjusting for diabetes mellitus, hypertension, and hyperlipidemia, the OR for prior statin use was 1.47 (95% CI 1.28-1.69) for cases compared with controls. Bell's palsy was significantly associated with previous regular statin use (≥60 days within 6 months) (adjusted OR: 1.46, 95% CI 1.28-1.67). However, there was no increased adjusted OR of irregular statin use (<60 days within 6 months) for cases compared with controls (OR: 1.09, 95% CI 0.82-1.46).<bold>Conclusions: </bold>Our present data suggest a potential association between regular statin use and Bell's palsy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01145916
- Volume :
- 37
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Drug Safety
- Publication Type :
- Academic Journal
- Accession number :
- 103844183
- Full Text :
- https://doi.org/10.1007/s40264-014-0212-5