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Different behaviour of NOX2 activation in patients with paroxysmal/persistent or permanent atrial fibrillation.
- Source :
- Heart; Jul2012, Vol. 98 Issue 14, p1063-1066, 4p
- Publication Year :
- 2012
-
Abstract
- BACKGROUND: NOX2, the catalytic subunit of NADPH oxidase, is suggested to play a role in favouring the occurrence of atrial fibrillation (AF) after cardiac surgery via formation of reactive oxidant species. However, its role in spontaneous AF is still unclear. OBJECTIVE: To define the role of NOX2 and isoprostanes, a marker of oxidative stress, in the different settings of AF. METHODS: The study was performed on 174 patients with AF (82 with paroxysmal/persistent AF and 92 with permanent AF) and 90 controls matched for sex, age and atherosclerotic risk factors. Urinary isoprostanes and serum levels of soluble NOX2-derived peptide (sNOX2-dp) were measured in each patient. RESULTS: Urinary isoprostanes and sNOX2-dp concentrations were significantly higher in patients with paroxysmal/persistent AF than in those with permanent AF and controls. Compared with controls, patients with permanent AF showed a weak increase in sNOX2-dp and no difference in isoprostanes. Multivariable analyses demonstrated that baseline values of sNOX2-dp and urinary isoprostanes were independently associated with the type of AF (paroxysmal/persistent vs permanent; [beta]=-224, p=0.007 and [beta]=-231, p=0.005, respectively). A significant correlation between sNOX2-dp levels and urinary excretion of isoprostanes was also detected (R=0.707, p<0.001). CONCLUSIONS: This study provides evidence that NOX2 is upregulated only in patients with paroxysmal/persistent AF and is responsible for overproduction of isoprostanes. This finding warrants further study to see if inhibition of NOX2 may reduce the risk of paroxysmal/persistent AF. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13556037
- Volume :
- 98
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- Heart
- Publication Type :
- Academic Journal
- Accession number :
- 104468873