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The Lifestyle Interventions and Independence for Elders Study: design and methods.

Authors :
Fielding RA
Rejeski WJ
Blair S
Church T
Espeland MA
Gill TM
Guralnik JM
Hsu FC
Katula J
King AC
Kritchevsky SB
McDermott MM
Miller ME
Nayfield S
Newman AB
Williamson JD
Bonds D
Romashkan S
Hadley E
Pahor M
Source :
Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Nov2011, Vol. 66A Issue 11, p1226-1237, 12p
Publication Year :
2011

Abstract

<bold>Background: </bold>As the number of older adults in the United States rises, maintaining functional independence among older Americans has emerged as a major clinical and public health priority. Older people who lose mobility are less likely to remain in the community; demonstrate higher rates of morbidity, mortality, and hospitalizations; and experience a poorer quality of life. Several studies have shown that regular physical activity improves functional limitations and intermediate functional outcomes, but definitive evidence showing that major mobility disability can be prevented is lacking. A Phase 3 randomized controlled trial is needed to fill this evidence gap.<bold>Methods: </bold>The Lifestyle Interventions and Independence for Elders (LIFE) Study is a Phase 3 multicenter randomized controlled trial designed to compare a supervised moderate-intensity physical activity program with a successful aging health education program in 1,600 sedentary older persons followed for an average of 2.7 years.<bold>Results: </bold>LIFE's primary outcome is major mobility disability, defined as the inability to walk 400 m. Secondary outcomes include cognitive function, serious fall injuries, persistent mobility disability, the combined outcome of major mobility disability or death, disability in activities of daily living, and cost-effectiveness.<bold>Conclusions: </bold>Results of this study are expected to have important public health implications for the large and growing population of older sedentary men and women. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10795006
Volume :
66A
Issue :
11
Database :
Complementary Index
Journal :
Journals of Gerontology Series A: Biological Sciences & Medical Sciences
Publication Type :
Academic Journal
Accession number :
104602819
Full Text :
https://doi.org/10.1093/gerona/glr123