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The Association of HIV Status with Bacterial Vaginosis and Vitamin D in the United States.
- Source :
- Journal of Women's Health (15409996); Oct2011, Vol. 20 Issue 10, p1497-1503, 7p
- Publication Year :
- 2011
-
Abstract
- Objective: To estimate the association between vitamin D deficiency and bacterial vaginosis (BV) among nonpregnant HIV-infected and uninfected women. Methods: In a substudy of the Women's Interagency HIV Study, including women from Chicago and New York, the association between BV and vitamin D deficiency, demographics, and disease characteristics was tested using generalized estimating equations. Deficiency was defined as <20 ng/mL 25 (OH) vitamin D and insufficiency as >20 and ≤30 ng/mL. BV was defined by the Amsel criteria. Results: Among 602 observations of nonpregnant women (480 HIV infected and 122 uninfected), BV was found in 19%. Vitamin D deficiency was found in 59.4%, and insufficiency was found in 24.4%. In multivariable analysis, black race was the most significant predictor of BV (adjusted odds ratio [AOR] 5.90, (95% confidence interval [CI] 2.52-13.8). Vitamin D deficiency was independently associated with BV among HIV-infected women (AOR 3.12, 95% CI 1.16-8.38) but not among HIV-uninfected women. There was a negative linear correlation between vitamin D concentration and prevalence of BV in HIV-infected women ( r=−0.15, p=0.001). Conclusions: Vitamin D deficiency was very common in this cohort and significantly associated with BV among HIV-infected women. These preliminary findings suggest that further epidemiologic and mechanistic exploration of the relationship between vitamin D and BV in HIV-infected women is warranted. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15409996
- Volume :
- 20
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Women's Health (15409996)
- Publication Type :
- Academic Journal
- Accession number :
- 104698727
- Full Text :
- https://doi.org/10.1089/jwh.2010.2685