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Association between interleukin-18 gene polymorphism 105A/C and asthma.
- Source :
- Clinical & Experimental Allergy; Aug2003, Vol. 33 Issue 8, p1097-1102, 6p
- Publication Year :
- 2003
-
Abstract
- Background IL-18 has been shown to exert anti-allergic or allergy-promoting activities, but the existence of genetic polymorphisms in the coding regions of IL-18 gene has not been demonstrated. Objective The aim of this study was to investigate whether polymorphism is present in the coding regions of the IL-18 gene and, if so, to further analyse the association between polymorphism and asthma in a case-control study. Methods We screened the coding regions of the IL-18 gene for polymorphisms by using PCRsingle-stranded conformation polymorphism and direct sequencing of PCR products, followed by analysis of the association between polymorphism and asthma. Results We identilied one polymorphism (105A/C) in the coding regions. The frequency of the 105A allele was significantly higher in asthmatic patients than in controls (p < 0.01; odds ratio (OR) = 1.83 (1.37-2.26)). Significant linkage disequilibrium was observed between the 105A/C and -137G/C polymorphisms in the 5' flanking region of the IL-18 gene (D = 0.58, P<0.0001). However, in asthmatic patients the 105A allele was not associated with either total serum IgE or IL-18 levels. Conclusion The 105A/C polymorphism of the IL-18 gene may be associated with the pathogenesis of asthma. [ABSTRACT FROM AUTHOR]
- Subjects :
- ASTHMA
INTERLEUKINS
RESPIRATORY allergy
GENETIC polymorphisms
IMMUNOLOGIC diseases
Subjects
Details
- Language :
- English
- ISSN :
- 09547894
- Volume :
- 33
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 10494334
- Full Text :
- https://doi.org/10.1046/j.1365-2222.2003.01739.x