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Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

Authors :
Luft VC
Schmidt MI
Pankow JS
Hoogeveen RC
Couper D
Heiss G
Duncan BB
Atherosclerosis Risk in Communities Investigators
Luft, Vivian C
Schmidt, Maria Inês
Pankow, James S
Hoogeveen, Ron C
Couper, David
Heiss, Gerardo
Duncan, Bruce B
Source :
Diabetes Care; May2010, Vol. 33 Issue 5, p1109-1111, 3p
Publication Year :
2010

Abstract

<bold>Objective: </bold>Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.<bold>Research Design and Methods: </bold>Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study.<bold>Results: </bold>In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors.<bold>Conclusions: </bold>Fasting DPP-IV levels do not appear to predict incident diabetes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01495992
Volume :
33
Issue :
5
Database :
Complementary Index
Journal :
Diabetes Care
Publication Type :
Academic Journal
Accession number :
105187759
Full Text :
https://doi.org/10.2337/dc09-1996