Acute encephalopathy associated with influenza A infection in adults.

Authors :: Lee N
Wong CK
Chan PK
Lindegardh N
White NJ
Hayden FG
Wong EH
Wong KS
Cockram CS
Sung JJ
Hui DS
Lee, Nelson
Wong, Chun Kwok
Chan, Paul K S
Lindegardh, Niklas
White, Nicholas J
Hayden, Frederick G
Wong, Edward H C
Wong, Ka Shing
Cockram, Clive S
Source :: Emerging Infectious Diseases; Jan2010, Vol. 16 Issue 1, p139-142, 4p
Publication Year :: 2010
Abstract: We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis. [ABSTRACT FROM AUTHOR]