Inhibitory activity on lipid peroxidation of extracts from marine brown alga.

Several extracts from marine brown alga Sargassum micracanthum (Kuetzing) Endlicher were screened for their inhibitory activity on lipid peroxidation. In an in vitro study, methanol extract (Sm-M), chloroform/ methanol (3:1) extract and ethyl acetate fraction of Sm-M inhibited lipid peroxidation in rat liver homo-genates. The IC₅₀ values were 0.70, 0.70 and 0.37 µg/mL, respectively. These inhibitions were stronger than vitamine C and E. These extracts showed reductive activity on DPPH, the IC₅₀ values were 34, 37 and 11 µg/mL, respectively. In an in vivo study, Sm-M had the effect on CCl4 induced liver injury in rats and Sm-M (120–1200 mg/kg, p.o.) lowered dose-dependently the level of lipid peroxidation in liver. Copyright © 2003 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]